University of Virginia
Research in our group focuses on the design and application of technologies used to build biomaterial and cellular systems that address biological, medical, and societal needs. We aim to design in vitro models of biological systems and to create cell and materials-based therapies to address injury and disease.
Our lab's work is rooted in biomaterials engineering, with a focus on designing material systems and processing materials both for use in, and also to advance, biofabrication technology. We are excited about work that unlocks potential of technologies, such as 3D printing, to impact basic and clinical research, for example in the creation of vascularized tissue constructs and in specifying heterogeneity within tissue constructs towards understanding biology, building better tissues in vitro, or enhancing outcomes in therapeutic applications. We benefit from great opportunities to collaborate with colleagues at UVA and further afield.
Our Areas of Research
work we've Published
| 35 | MG Grewal, VP Gray, RA Letteri, CB Highley User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes Biomaterials Science, Volume 9, Issue 12, 2021, Pages 4374-4387, doi: 10.1039/D1BM00016K |
| 34 | B Miller, A Hansrisuk, CB Highley, SR Caliari Guest–Host Supramolecular Assembly of Injectable Hydrogel Nanofibers for Cell Encapsulation in press at ACS Biomaterials Science & Engineering, Volume X, Issue XX, 2021, Pages XXX-XXX, doi: 10.1021/acsbiomaterials.1c00275 |
| 33 | MG Grewal, CB Highley Electrospun hydrogels for dynamic culture systems: advantages, progress, and opportunities Biomaterials Science, Volume 9, Issue 12, 2021, Pages 4228-4245, doi: 10.1039/D0BM01588A |
| 32 | BN Pfaff, LJ Pruett, NJ Cornell, J De Rutte, D Di Carlo, CB Highley, DR Griffin Selective and Improved Photoannealing of Microporous Annealed Particle (MAP) Scaffolds ACS Biomaterials Science & Engineering, Volume 7, Issue 2, February 2021, Pages 422-427 |
| 31 | A McCormack, CB Highley, R Leslie, FPW Melchels 3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat Trends in Biotechnology, Volume 38, Issue 6, June 2020, Pages 584-593 |
| 30 | RK Bour, PR Sharma, JS Turner, WE Hess, EL Mintz, CR Latvis, BR Shepherd, SC Presnell, MJ McConnell, C Highley, SM Peirce, GJ Christ Bioprinting on sheet-based scaffolds applied to the creation of implantable tissue-engineered constructs with potentially diverse clinical applications: Tissue-Engineered Muscle Repair (TEMR) as a representative testbed Connective Tissue Research Volume 61, Issue 2, January 2020, Pages 216-228 |
| 29 | CB Highley 3D Bioprinting Technologies chapter in 3D Bioprinting in Medicine, August 2019, Pages 1-66 |
lab news
The Caliari lab has posted a preprint on bioRxiv on work developing injectable hydrogel fibers for cell encapsulation; we enjoyed the opportunity to contribute and look forward to future collaborative efforts developing and applying soft materials.
Jan 2021
Greg has published a review in Biomaterials Science describing research at the forefront of using electrospun fibers based on hydrogel biomaterials and their great potential in tissue engineering/regenerative medicine and fundamental studies of cellular behavoirs. Nice job, Greg.
Jan 2021
Excited to contribute to work in the Griffin lab developing chemistries for annealing microporous particle gels by looking at how these chemistries affect application in extrusion-based printing, recently published in ACS Biomaterials Science and Engineering. We're looking forward to continued work together on these cutting-edge material systems.
contact us
Chris's office:
Jesser Hall (formerly: Materials Science Building)
Room 249
[Green marker on map below]
Mailing address:
385 McCormick Road
CER 025, POB 400741
Charlottesville, Virginia 22903
Email:
highley@virginia.edu
Phone | fax:
434-243-3045 | 434-982-2658
Grads' office (the "lab office"):
Chemistry Building
Room 145
[Blue marker to the left on map below]
Mailing address:
385 McCormick Road
CER 025, POB 400741
Charlottesville, Virginia 22903
Phone:
434-243-6576